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Crocin & Saffron Health News | Latest Research, Events & Product Updates

Welcome to the official source for crocin & saffron supplement breakthroughs. Here you’ll find the latest — peer-reviewed crocin studies, product launches, regulatory milestones, and expert insights to help you understand how saffron might support vision, cognitive health, mood, and healthy aging.

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Recent Product & Company News

Jan 20, 2024: Join us at Booth #8323 in the Hot Products Section on ACC Level 3 at Natural Products EXPO WEST, Anaheim Convention Center, CA, from March 13-15, 2024. Explore our revolutionary crocin-based supplements for a healthier, more vibrant future!🌟🌿

Sept. 14, 2023: FDA issued Certificate of Free Sale for our optimized all natural product line: CROCIN RICH, CROCIN RICH II and CROCIN RICH plus. 

Sept. 5, 2023: Our new version of crocin supplements were launched. These new adjusted products with optimized formulation are all natural, non-GMO, with no artificial colorants, and are gluten-free.

Sept. 2022: Increased daily usage of Crocin Rich®, a natural and only water-soluble carotenoid crocin, was given "No Objections" by the FDA as a new dietary ingredient (NDI).

Jan. 18, 2022: The FDA issued a Closeout Letter to Warning Letter #615429 after we promptly removed disease-name references from educational blog content and citations of published studies. Our supplement formulations, labeling, and product safety were not at issue, as they remain fully compliant and based on sound science and clinical research.

Nov. 18, 2020: The FDA issued Warning Letter #615429 to Saffron Health Sciences, citing certain educational blog and website content that referenced disease names within clinical study descriptions. While scientifically accurate, such references are not permitted under FDA regulations when appearing on commercial sites that sell dietary supplements, as they may be interpreted as unauthorized disease claims.

Nov. 2020: A US Patent was issued for our product.

Jan. 2017: Published “A Perspective on Crocus sativus L. (Saffron) Constituent Crocin: A Potent Water-Soluble Antioxidant ...” J. Agric. Food Chem. 2017, 65, 1005−1020.

Mar. 2016: FDA issued Certificate of Free Sale for Products: CROCIN RICH, CROCIN RICH II and CROCIN RICH plus.

Dec. 2015: US patent 9,211,298 was issued for our product.

Sep. 2015: FDA reviewed and granted (NO Objection) to Crocin Rich®, the purified natural crocin ingredient, as a new dietary ingredient (NDI) for product application. Crocin is the only water-soluble carotenoid in nature.


Latest Crocin & Saffron Research

01/2025 A 90-day study of crocin supplementation in human subjects indicated positive impact on macular health and glycemic profile. J Pharm Care 2024; 12(4): 204-212. https://doi.org/10.18502/jpc.v12i4.17451

12/2024 A pilot randomized double blinded clinical trial demonstrated crocin supplementation supports visual acuity and ameliorates eye strain and retinal stress. PharmaNutrition. Volume 30, December 2024, 100422. https://doi.org/10.1016/j.phanu.2024.100422  

11/2024 The beneficial effects of crocin supplementation on metabolic health: A randomized double-blind controlled clinical trial. Journal of Functional Foods. Volume 122, November 2024, 106507. https://doi.org/10.1016/j.jff.2024.106507

9/2024 The Effect of Crocin on Movements, Balance and Coordination: Insights from a Randomized Controlled Trial. https://doi.org/10.1016/j.parkreldis.2024.107051

2/2024 Crocin supplementation on intraocular pressure: a randomized, triple-blind, placebo-controlled clinical trial. Medicine in Drug Discovery, 21 (2024) 100169. https://doi.org/10.1016/j.medidd.2023.100169

2023 Effect of crocin of Crocus sativus L. on regulating inflammation, lung function, and exercise capacity: a randomised, double-blind, placebo-controlled trial. British Journal of Nutrition , First View , pp. 1 – 8. 2023. DOI: https://doi.org/10.1017/S0007114522003397 

1/2023 The Effects of Crocin Supplementation on Sleep Quality, General Health, and Happiness in Elderly Population: A Randomized, Double-blind, Placebo-controlled Trial. Intl J Med Toxicol and Fore Med. 2023; 13(1):E38718. https://doi.org/10.32598/ijmtfm.v12i4.38718

3/2022 Crocin as a vision supplement. Clinical and Experimental Optometry, DOI: 10.1080/08164622.2022.2039554

8/2021 Saffron improves life and sleep quality, glycaemic status, lipid profile and liver function: A double-blind, placebo-controlled, randomised clinical trial. Intl. J. Clin Prac. 2021, 75(8): e14334. https://doi.org/10.1111/ijcp.14334.

1/2020 The effects of crocus sativus extract (crocin) on lipid profile and liver functions: A randomized placebo-controlled study. Obe Med. 2020, 17, 100165. https://doi.org/10/1016/j.obmed.2019.100165

12/2018 Effect of crocetin on quality of sleep: A randomized, double-blind, placebo-controlled, crossover study. Complement Ther Med. 2018, 41: 47-51. doi: 10.1016/j.ctim.2018.09.003

Hundreds of recently published clinical and preclinical studies of crocin/saffron on eye health, memory, cognitive health, mood, sleep quality, quality of life, etc. in the peer-reviewed scientific and medical journals can be found by searching Google Scholar. 

Why It Matters — How This Research Relates to You

Modern saffron research has grown rapidly in the past decade, with dozens of human studies exploring how crocin, saffron’s key active compound, supports different aspects of well-being. While our website cannot directly provide the findings and conclusions from those clinical studies in order to comply dietary supplement regulations, we can explain what these studies suggest in simple, practical terms.

Here’s what today’s crocin science means for you:

⭐ Supports Visual Performance & Eye Comfort

Many studies investigate crocin’s effects on visual function, macular performance, and eye comfort, especially for people dealing with screen time or age-related visual strain.
→ Learn more: How Crocin Supports Visual Health and Crocin/saffron supplementation performs better than AREDS2 

⭐ Helps Maintain Emotional Balance & Positive Mood

Published saffron research frequently evaluates crocin’s impact on mood, emotional balance, and stress support, making it one of today’s most promising natural mood-supportive nutrients.
→ Learn more: Crocin for Mood Support

⭐ Supports Memory, Clarity & Cognitive Performance

Research suggests crocin may play a role in focus, mental clarity, memory performance, and general cognitive support, making it appealing for students, professionals, and older adults.
→ Learn more: Crocin & Cognitive Health

⭐ Supports Smooth Movement & Motor Coordination

Multiple modern studies explore crocin’s role in movement control, coordination, and nerve function, areas important for healthy aging and active lifestyles.
→ Learn more: Crocin for Movement Support

⭐ Promotes Daily Vitality & Healthy Aging

Crocin’s unique antioxidant profile (water-soluble carotenoid) is being studied for its potential to support overall vitality, energy, and healthy aging in adults.
→ Learn more: Crocin & Healthy Aging

Crocin research is expanding because people increasingly want natural, science-backed support for vision, focus, mood, movement, and aging. This page brings you the newest studies so you can stay informed and make confident decisions.

Explore Our Products

Everything we create is built around Crocin Rich® — our high-purity crocin ingredient recognized by the FDA as a New Dietary Ingredient (NDI) and used in clinical research levels.

Choose the formula that fits your needs:

👁️ CROCIN RICH — Advanced Eye & Visual Support

High-purity crocin + lutein + zeaxanthin for adults seeking support for visual clarity, macular performance, screen fatigue, and comfortable day-to-day vision.

  • Eye comfort
  • Visual performance
  • Macular support
  • Healthy eye pressure support

→ Shop CROCIN RICH

🧠 CROCIN RICH Plus — Mood, Focus & Daily Vitality Support

U.S.-patented high-potency crocin formula with 7 additional antioxidants for broad support in mood, clarity, sleep quality, movement, and healthy aging.

  • Memory & focus
  • Mood balance
  • Sleep quality
  • Movement support

→ Shop CROCIN RICH Plus

⚡ CROCIN RICH II — Mobility, Cognitive & Healthy Aging Support

Highly pure crocin enhanced with piperine for adults concerned with movement comfort, cognitive clarity, and whole-body vitality.

  • Motor & movement support
  • Brain & nerve support
  • Eye health support
  • Daily vitality

→ Shop CROCIN RICH II

❤️ Your Health, Backed by Science

We formulate every product with clinically relevant crocin levels, clean ingredients, and U.S.-based cGMP manufacturing — so you can feel confident, informed, and supported on your wellness journey.