Crocin & Saffron News

Here you can find the most recent news about our product developments and crocin/saffron related research publications. 

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Our Product News

Nov. 2020: A US Patent was issued for our product.

Jan. 2017: Published “A Perspective on Crocus sativus L. (Saffron) Constituent Crocin: A Potent Water-Soluble Antioxidant and Potential Therapy for Alzheimer’s Disease” J. Agric. Food Chem. 2017, 65, 1005−1020.

Mar. 2016: FDA issued Certificate of Free Sale for Products: CROCIN RICH, CROCIN RICH II and CROCIN RICH plus.

Dec. 2015: US patent 9,211,298 was issued for our product.

Sep. 2015: FDA reviewed and approved (NO Objection) Crocin Rich®, the purified natural crocin ingredient, as a new dietary ingredient (NDI) for product application. Crocin is the only water-soluble carotenoid in nature, a potent antioxidant and anti-inflammatory agent.


Crocin and Saffron Research Publications

9/2021 Effectiveness of crocin of saffron (Crocus sativus L.) against chemotherapy-induced peripheral neuropathy: A randomized, double-blind, placebo-controlled clinical trial. Journal of Ethnopharmacology. 2021, 281: 114511. https://doi.org/10.1016/j.jep.2021.114511

8/2021 Comparing the Therapeutic Effects of Crocin, Escitalopram and Co-Administration of Escitalopram and Crocin on Learning and Memory in Rats with Stress-Induced Depression. Malays J Med Sci. 2021;28(4):50–62. https://doi.org/10.21315/mjms2021.28.4.6

7/2021 Inflammatory markers response to crocin supplementation in patients with type 2 diabetes mellitus: A randomized controlled trial. Phytotherapy Research. 2021, 35(7), 4022-4035. https://doi.org/10.1002/ptr.7124

7/2021 Effect of crocin versus fluoxetine in treatment of mild to moderate obsessive-compulsive disorder: A double blind randomized clinical trial. Human Psychopharmacology. 2021, 36(4): e2780. https://doi.org/10.1002/hup.2780

6/2021 Amelioration of anxiety, depression, and chemotherapy related toxicity after crocin administration during chemotherapy of breast cancer: A double blind, randomized clinical trial. Phytotherapy Research. 2021, https://doi.org/10.1002/ptr.7180

6/2021 Administering crocin ameliorates anxiety-like behaviours and reduces the inflammatory response in amyloid-beta induced neurotoxicity in rat. Clin Exp Pharm Phys. 2021, 48(6): 877-889. https://doi.org/10.1111/1440-1681.13494.

6/2021 Protective effects of crocin against endogenous Aβ-induced neurotoxicity in N2a/APP695swe cells. Psychopharmacology. 2021, 238: 2839–2847

6/2021 The effect of crocin on hippocampal lipid peroxidation and histopathology following intracerebroventricular injection of colchicine in the rat. Journal of Basic and Clinical Pathophysiology. 2021, 9(1): 10.22070/JBCP.2020.4968.1124.

5/2021 Protective effect of crocin against mitochondrial damage and memory deficit induced by beta-amyloid in the hippocampus of rats. IJPR. 2021, http://ijpr.sbmu.ac.ir/article_1101370.html 

5/2021 Protective Effect of Crocin on Liver Function and Survival in Rats With Traumatic Hemorrhagic Shock. Journal of Surgical Research. 2021, 261: 301-309

5/2021 A Review on the Effective Properties of Crocin in the Management of Cardiopulmonary Dysfunction. Jundishapur Journal of Physiology (JJP). 2021, 2(1); 22-28. https://jjphysiology.ajums.ac.ir/article_131753_dd26ce38c053571617f49d5159e38aa0.pdf

4/2021 Investigating the effect of crocin on memory deficits induced by total sleep deprivation (TSD) with respect to the BDNF, TrkB and ERK levels in the hippocampus of male Wistar rats. J of Psychopharm. 2021, https://doi.org/10.1177/02698811211000762.

4/2021 Crocin attenuates the granular cells damages on the dentate gyrus and pyramidal neurons in the CA3 regions of the hippocampus and frontal cortex in the rat model of Alzheimer's disease. Journal of Chemical Neuroanatomy. 2021, 113: 101837

3/2021 Crocin Administration from Childhood to Adulthood Increases Hippocampal Neurogenesis and Synaptogenesis in Male Mice. J of Kerman Univ of Med Sci. 2021; 28(3):243-251.

3/2021 Administering crocin ameliorates anxiety‐like behaviors and reduces the inflammatory response in amyloid‐beta induced neurotoxicity in rat. Clin Exp Pharm Physi, 2021 https://doi.org/10.1111/1440-1681.13494.

3/2021 Exercise and crocin prevent adolescent-stress induced impairment of spatial navigation and dendritic retraction in the hippocampal CA3 area in adult male rats. Brain Research. 2021, 1754, 147274.

2/2021 Effects of crocin on spatial or aversive learning and memory impairments induced by lipopolysaccharide in rats. Avicenna J of Phytomed, 2021, 11(1): 79-90.

2/2021 Crocin mitigated cognitive impairment and brain molecular alterations induced by different intensities of prenatal hypoxia in neonatal rats. Brain and Behavior. 2021, https://doi.org/10.1002/brb3.2078.

2/2021 Crocus sativus L. Extracts and Its Constituents Crocins and Safranal; Potential Candidates for Schizophrenia Treatment? Molecules 2021, 26(5), 1237; https://doi.org/10.3390/molecules26051237

2/2021 Enhanced Neural Differentiation of Epidermal Neural Crest Stem Cell by Synergistic Effect of Lithium carbonate and Crocin on BDNF and GDNF Expression as Neurotrophic Factors. Iranian Journal of Pharmaceutical Research. 2021, 20 (2): 95-106.

1/2021 Crocins, the Bioactive Components of Crocus sativus L., Counteract the Disrupting Effects of Anesthetic Ketamine on Memory in Rats. Molecules. 2021, 26, 528. https://doi.org/10.3390/molecules26030528.

1/2021 Crocetin promotes clearance of amyloid-β by inducing autophagy via the STK11/LKB1-mediated AMPK pathway. Autophagy. 2021, https://doi.org/10.1080/15548627.2021.1872187.

10/2020 Saffron for the management of premenstrual dysphoric disorder: A randomized controlled trial. Advanced Biomedical Research. 2020, October, IP: 241.68.254.246

10/2020 The effect of crocin (the main active saffron constituent) on the cognitive functions, craving, and withdrawal syndrome in opioid patients under methadone maintenance treatment. Phyto Res 2020, https://doi.org/10.1002/ptr.6913.

10/2020 The effect of crocin on memory, hippocampal acetylcholine level, and apoptosis in a rat model of cerebral ischemia. Biomedicine & Pharmacotherapy. 2020, 130, 110543

9/2020 The effect of crocin supplementation on glycemic control, insulin resistance and active AMPK levels in patients with type 2 diabetes: a pilot study. Diabetol Metab Syndr. 2020, 12:59 https://doi.org/10.1186/s13098-020-00568-6

9/2020 Ameliorative effects of crocin on tartrazine dye–induced pancreatic adverse effects: a biochemical and histological study. Environ Sci Pollut Res. 2021, 28, 2209–2218.

8/2020 The effect of crocin supplementation on lipid concentrations and fasting blood glucose: A systematic review and meta-analysis and meta-regression of randomized controlled trials. Complementary Therapies in Medicine. 2020, 52, 102500.

8/2020 The effect of saffron supplementation on some inflammatory and oxidative markers, leptin, adiponectin, and body composition in patients with nonalcoholic fatty liver disease: A double‐blind randomized clinical trial. Phytother Res. 2020 https://doi.org/10.1002/ptr.6791

8/2020 A placebo controlled randomized clinical trial of Crocus sativus L. (saffron) on depression and food craving among overweight women with mild to moderate depression. J Clin Pharm Ther. 2020; 45: 134–143.

8/2020 Crocin Treatment after Maternal Hypoxia Attenuates Spatial Memory Impairment and Expression of BACE1 and HIF-1a in Rat Offspring Brain. Basic & Clin Neurosci. 2020, 11(4):499-406.

7/2020 The effect of saffron supplement on clinical outcomes and metabolic profiles in patients with active rheumatoid arthritis: A randomized, double‐blind, placebo‐controlled clinical trial. Phytother Res. 2020 Jul; 34(7): 1650-1658.

6/2020  Immunoregulatory Effects of Krocina™, a Herbal Medicine Made of Crocin, on Osteoarthritis Patients: A Successful Clinical Trial in Iran. Iran J Allergy Asthma Immunol. 2020, 19(3): 253-263.

6/2020 Neuroprotective effects of saffron on the late cerebral ischemia injury through inhibiting astrogliosis and glial scar formation in rats. Biomedicine & Pharmacotherapy. 2020, 126, 110041

5/2020  Effects of crocin and saffron aqueous extract on gene expression of SIRT1, AMPK, LOX1, NF-κB, and MCP-1 in patients with coronary artery disease: A randomized placebo-controlled clinical trial. Phytother Res. 2020, 34(5): 1114-1122.

5/2020  Effects of saffron (Crocus sativus L.) on cognitive function. A systematic review of RCTs. Neurological Sciences. 2020, 41: 2747–2754

5/2020  Pharmacological Effects of Saffron and Its Constituents in Ocular Disorders From in Vitro Studies to Clinical Trials; A Systematic Review. Curr Neuropharmacol. 2020 May 6.  doi: 10.2174/1570159X18666200507083346.

4/2020  Effects of saffron supplementation on glycemia and inflammation in patients with type 2 diabetes mellitus: A randomized double-blind, placebo-controlled clinical trial study. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. Available online 29 April 2020

3/2020  The effects of crocus sativus extract on serum lipid profile and liver enzymes in patients with non-alcoholic fatty liver disease: A randomized placebo-controlled study. Obesity Medicine. Volume 17, March 2020, 100165

3/2020  Effect of crocin on antioxidant gene expression, fibrinolytic parameters, redox status and blood biochemistry in nicotinamide-streptozotocin-induced diabetic rats. J of Biol Res-Thessaloniki, 2020, 27, 4. https://doi.org/10.1186/s40709-020-00114-5

2/2020  The effect of saffron supplement on clinical outcomes and metabolic profiles in patients with active rheumatoid arthritis: A randomized, double‐blind, placebo‐controlled clinical trial. Phytother. Res. 2020, https://doi.org/10.1002/ptr.6633

2/2020  Effects of Saffron on Sleep Quality in Healthy Adults With Self-Reported Poor Sleep: A Randomized, Double-Blind, Placebo-Controlled Trial. Journal of Clinical Sleep Medicine. 2020, https://doi.org/10.5664/jcsm.8376

2/2020  Cytotoxic and osteogenic effects of crocin and bicarbonate from calcium phosphates for potential chemopreventative and anti-inflammatory applications in vitro and in vivo. J Mater Chem B. 2020, 8(10):2048-2062.

1/2020  Crocin: a protective natural antioxidant against pulmonary fibrosis induced by bleomycin. Pharmacol. Rep (2020). https://doi.org/10.1007/s43440-019-00023-y

1/2020  Crocin attenuates isoprenaline-induced myocardial fibrosis by targeting TLR4/NF-κB signaling: connecting oxidative stress, inflammation, and apoptosis. Naunyn-Schmiedeberg's Archives of Pharmacology, 2020, 393: 13–23

1/2020  Beneficial effects of saffron (Crocus sativus L.) in ocular pathologies, particularly neurodegenerative retinal diseases. Neural Regen Res. 2020, 15(8): 1408-1416.

1/2020  Neuroprotective effect of crocin against rotenone-induced Parkinson's disease in rats: Interplay between PI3K/Akt/mTOR signaling pathway and enhanced expression of miRNA-7 and miRNA-221. Neuropharmacology. 2020, 164: 107900

1/2020  Crocin prevents metabolic syndrome in rats via enhancing PPAR-gamma and AMPK. Saudi Journal of BiologicalSciences,https://doi.org/10.1016/j.sjbs.2020.01.004

12/2019 Effects of crocin in reducing DNA damage, inflammation, and oxidative stress in multiple sclerosis patients: A double-blind, randomized, and placebo-controlled trial. J Biochem Mol Toxicol. 2019 Dec;33(12):e22410. doi: 10.1002/jbt.22410.

11/2019 Evaluation of the effectiveness of crocin isolated from saffron in treatment of burning mouth syndrome: A randomized controlled trial. Avicenna J Phytomed, 2019; 9(6): 505-516

10/2019 Effects Of Saffron Supplementation On Inflammation And Metabolic Responses In Type 2 Diabetic Patients: A Randomized, Double-Blind, Placebo-Controlled Trial. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2019, 12: 2107–2115

6/2019  Protective properties of the aqueous extract of saffron (Crocus sativus L.) in ischemic stroke, randomized clinical trial. J Ethnopharm. 2019, 238, https://doi.org/10.1016/j.jep.2019.111833

5/2019   Effects of saffron on homocysteine, and antioxidant and inflammatory biomarkers levels in patients with type 2 diabetes mellitus: a randomized double-blind clinical trial. Avicenna J Phytomed, 2019. Epub ahead of print.

5/2019   Evaluation of the effectiveness of crocin isolated from saffron in treatment of burning mouth syndrome: A randomized controlled trial. Avicenna J Phytomed, 2019. Epub ahead of print.

5/2019   Crocin, a carotenoid, suppresses spindle microtubule dynamics and activates the mitotic checkpoint by binding to tubulin. Biochemical Pharmacology. 2019, 163: 32-45.

4/2019   Crocus sativus L. Versus Methylphenidate in Treatment of Children with Attention-Deficit/Hyperactivity Disorder: A Randomized, Double-Blind Pilot Study. Journal of Child and Adolescent Psychopharmacology. 2019, 29(3). https://doi.org/10.1089/cap.2018.0146

4/2019   Saffron: The Golden Spice with Therapeutic Properties on Digestive Diseases. Nutrients 2019, 11, 943; doi:10.3390/nu11050943.

4/2019   Beneficial Effects of Physical Activity and Crocin Against Adolescent Stress Induced Anxiety or Depressive-Like Symptoms and Dendritic Morphology Remodeling in Prefrontal Cortex in Adult Male Rats. Neurochemical Research. 2019, 44(4): 917–929.

3/2019   Saffron (Crocus sativus L.) in Ocular Diseases: A Narrative Review of the Existing Evidence from Clinical Studies. Nutrients. 2019, 11, 649; doi:10.3390/nu11030649

3/2019   Protective properties of the aqueous extract of saffron (Crocus sativus L.) in ischemic stroke, randomized clinical trial. Journal of Ethnopharmacology. Available online 23 March 2019, 111833

3/2019   Crocin may be useful to prevent or treatment of alcohol induced neurodegeneration and neurobehavioral sequels via modulation of CREB/BDNF and Akt/GSK signaling pathway. Medical Hypotheses. 2019, 124: 21-25.

3/2019   The Crocus sativus Compounds trans-Crocin 4 and trans-Crocetin Modulate the Amyloidogenic Pathway and Tau Misprocessing in Alzheimer Disease Neuronal Cell Culture Models. Frontiers in Neuroscience. 2019, https://doi.org/10.3389/fnins.2019.00249.

3/2019   Crocin inhibits the migration, invasion, and epithelial‐mesenchymal transition of gastric cancer cells via miR‐320/KLF5/HIF‐1α signaling. J Cell Phys. https://doi.org/10.1002/jcp.28418.

2/2019   The effects of crocin on psychological parameters in patients under methadone maintenance treatment: a randomized clinical trial. Subst Abuse Treat Prev Policy. 2019; 14: 9. doi: 10.1186/s13011-019-0198-1

2/2019   An evaluation of the effects of saffron supplementation on the asthma clinical symptoms and asthma severity in patients with mild and moderate persistent allergic asthma: a double-blind, randomized placebo-controlled trial. Respiratory Research. 2019, 20:39.

2/2019   Crocin-protected malathion-induced spatial memory deficits by inhibiting TAU protein hyperphosphorylation and antiapoptotic effects. Nutritional Neuroscience. 2019, https://doi.org/10.1080/1028415X.2018.1492772

2/2019   Crocin Acts as a Neuroprotective Agent against Methamphetamine-induced Neurodegeneration via CREB-BDNF Signaling Pathway. IJPR. 2019, DOI: 10.22037/IJPR.2019.2393

2/2019   Crocin as a novel therapeutic agent against colitis. Drug and Chemical Toxicology. 2019, https://doi.org/10.1080/01480545.2018.1527850.

1/2019   Saffron therapy for the treatment of mild/moderate age-related macular degeneration: a randomised clinical trial. Graefe's Archive for Clinical and Experimental Ophthalmology. 2019, 257(1): 31–40.

1/2019   Pretreatment with crocin along with treadmill exercise ameliorates motor and memory deficits in hemiparkinsonian rats by anti-inflammatory and antioxidant mechanisms. Metabolic Brain Disease, 2019, 34(2): 459-468.

1/2019   The effects of crocin on spatial memory impairment induced by hyoscine: Role of NMDA, AMPA, ERK and CaMKII proteins in rat hippocampus. Iran J Basic Med Sci 2019; 22:1-9.

1/2019   Investigation of the neuroprotective effects of crocin via antioxidant activities in HT22 cells and in mice with Alzheimer’s disease. Intl J Mol Med. 2019, 43: 956-966.

1/2019   Therapeutic potency of crocin in the treatment of inflammatory diseases: Current status and perspective. J Cell Phys. 2019 https://doi.org/10.1002/jcp.28177.

1/2019   The Efficacy of Saffron in the Treatment of Mild to Moderate Depression: A Meta-analysis. Planta Med 2019; 85(01): 24-31.

12/2018   Crocin inhibits apoptosis and astrogliosis of hippocampus neurons against methamphetamine neurotoxicity via antioxidant and anti-inflammatory mechanisms. Neurochemical Research. 2018, 43(12): 2252–2259.

12/2018   Effects of Combined Crocin and Epirubicin on Apoptosis and Cell Cycle Pathways in a Human Cervical Cancer Cell Line. Int J Cancer Manag. 2018, 11(12): e82575.

11/2018   Effects of crocin on cognitive and spatial memories in rats under chronic isolation stress. Physiology and Pharmacology. 2018, 22: 254-268

11/2018   Antiviral Effects of Saffron and its Major Ingredients. Current Drug Delivery. 2018, 15(5): 698-704

10/2018   Effect of Crocin, Exercise, and Crocin-accompanied Exercise on Learning and Memory in Rats under Chronic Unpredictable Stress. Adv Biomed Res. 2018; 7: 137. doi: 10.4103/abr.abr_153_18.

10/2018   The effect of crocin on total sleep-deprivation induced amnesia in male Wistar rats. Journal of Paramedical Sciences. 2018, 9(4). ISSN 2008-4978

10/2018   Neuroprotection against CCl4 induced brain damage with crocin in Wistar rats. Biotechnic & Histochemistry. 2018, 93(8). https://doi.org/10.1080/10520295.2018.1519725.

9/2018   Treatment with crocin improves cardiac dysfunction by normalizing autophagy and inhibiting apoptosis in STZ-induced diabetic cardiomyopathy. Nutrition, Metabolism & Cardiovascular Diseases. 2018, 28(9): 952–961

9/2018   Crocin, a natural product attenuates lipopolysaccharide-induced anxiety and depressive-like behaviors through suppressing NF-kB and NLRP3 signaling pathway. Brain Research Bulletin. 2018, 142: 352-359.

8/2018   Effects of Crocins in the Management of Neurodegenerative Pathologies: A Review. Neurophysiology. 2018, 50(4): 302–308

8/2018   Effects of the active constituents of Crocus sativus L. crocins and their combination with memantine on recognition memory in rats. Behavioural Pharmacology. 2018, 29(5): 400-412.

6/2018   Effects of Crocin on Diabetic Maculopathy: A Placebo-Controlled Randomized Clinical Trial. Am J of Ophth. 2018, 190: 89-98

5/2018    Crocin improved amyloid beta induced long-term potentiation and memory deficits in the hippocampal CA1 neurons in freely moving rats. Synapse. 2018, 72(5). doi.org/10.1002/syn.22026.

5/2018   affron®, a standardised extract from saffron (Crocus sativus L.) for the treatment of youth anxiety and depressive symptoms: A randomised, double-blind, placebo-controlled study. Journal of Affective Disorders. 2018, 232: 349-357

5/2018   Crocin attenuates cyclophosphamide induced testicular toxicity by preserving glutathione redox system. Biomedicine & Pharmacotherapy. 2018, 101: 174-180

3/2018   Preventive effects of crocin on neuronal damages induced by D-galactose through AGEs and oxidative stress in human neuroblastoma cells (SH-SY5Y). J Pharmacopuncture. 2018, 21(1): 18–25.

3/2018   Efficacy of Crocus sativus (saffron) in treatment of major depressive disorder associated with post-menopausal hot flashes: a double-blind, randomized, placebo-controlled trial. Archives of Gynecology and Obstetrics. 2018, 297(3): 717–724

3/2018   Crocin improves the proliferation and cytotoxic function of T cells in children with acute lymphoblastic leukemia. Biomedicine & Pharmacotherapy. 2018, 99: 96-100

3/2018   Anticancer activity of crocin against cervical carcinoma (HeLa cells): Bioassessment and toxicity evaluation of crocin in male albino rats. J of Photochem and Photobio B: Biology. 2018, 180: 118-124

2/2018   The effects of tramadol administration on hippocampal cell apoptosis, learning and memory in adult rats and neuroprotective effects of crocin. Metabolic Brain Disease. 2018, 33: 907–916

2/2018   Crocin potentiates antioxidant defense system and improves oxidative damage in liver tissue in diabetic rats. Biomedicine & Pharmacotherapy. 2018, 98: 333-337.

2/2018   Saffron improved depression and reduced homocysteine level in patients with major depression: A Randomized, double-blind study. Avicenna J Phytomed. 2018, 8(1): 43–50.

1/2018   Dietary crocin reverses melanoma metastasis. J of Biomed Res, 2018, 32(1): 39–50

1/2018   Crocin attenuates acute hypobaric hypoxia-induced cognitive deficits of rats. European Journal of Pharmacology. 2018, 818: 300-305.

1/2018   Protective effect of crocin against d-galactose-induced aging in mice. Avicenna J Phytomed. 2018, 8(1): 14–23.

12/2017   The effect of crocin on forgetfulness caused by cholestasis in male rats (behavioral , biochemical and genetical). The First International Congress on Biomedicine held from November 22th to 24th, 2017 in Tehran, Iran.

12/2017   Yorgun MA, Rashid K, Aslanidis A, Bresgen C, Dannhausen K, Langmann T. Crocin, a plant-derived carotenoid, modulates microglial reactivity. Biochemistry and Biophysics Reports. 2017, 12: 245–250.

11/2017   Effect of saffron oral capsule on anxiety and quality of sleep of diabetic patients in a tertiary healthcare facility in southeastern Iran: A quasi-experimental study. Trop J Pharm Res, 2017; 16(11): 2749-2753.

11/2017   Effect of Saffron Extract and Aerobic Exercises on Troponin T and Heart-Type Fatty Acid Binding Protein in Type 2 Diabetes Patients. Iranian Journal of Diabetes & Obesity. 2017, 9(1/2): 45-53.

11/2017   The Psychoactive Agent Crocin Can Regulate Hypothalamic-Pituitary-Adrenal Axis Activity. Frontiers in Neuroscience. 2017, 11 | Article 668. doi: 10.3389/fnins.2017.00668

11/2017   Heidari  S, Mehri S, Hosseinzadeh H. Memory enhancement and protective effects of crocin against D-galactose aging model in the hippocampus of Wistar rats. Iran J Basic Med Sci, 2017, 20(11): 1250-1259.

11/2017   Effects of saffron and its constituents, crocin-1, crocin-2, and crocetin on α-synuclein fibrils. Journal of Natural Medicines. (2017). https://doi.org/10.1007/s11418-017-1150-1.

10/2017   Effect of Saffron (Crocus sativus L.) as an Add-On Therapy to Sertraline in Mild to Moderate Generalized Anxiety Disorder: A Double Blind Randomized Controlled Trial. Arch Neurosci. 2017 4(4):e14332. doi: 10.5812/archneurosci.14332.

9/2017   The effect of saffron on sexual dysfunction in women of reproductive age. Nurs Pract Today. 2017; 4(3):154-163.

9/2017     Mashak shahabadi M, Mousavi SZ, Mousavi SE, Ezzati MH. Crocin Affects Passive Avoidance Memory Following Formaldehyde-Induced Neurotoxicity in a Rat Model. Advanced Journal of Toxicology: Current Research. 2017, 1(1): 15-22.

8/2017    Saffron (Crocus sativus) intake provides nutritional preconditioning against myocardial ischemia-reperfusion injury in Wild Type and ApoE(-/-) mice: Involvement of Nrf2 activation. Nutrition, Metabolism & Cardiovascular Diseases. 2017, 27: 919-929.

8/2017    Comparison of Saffron and Fluvoxamine in the Treatment of Mild to Moderate Obsessive-Compulsive Disorder: A Double Blind Randomized Clinical Trial. Iran J Psychiatry 2017, 12(3): 154-162.

8/2017     affron® a novel saffron extract (Crocus sativus L.) improves mood in healthy adults over 4 weeks in a double-blind, parallel, randomized, placebo-controlled clinical trial. Complementary Therapies in Medicine. 2017, 33: 58-64.

8/2017     Crocin Attenuates Joint Pain and Muscle Dysfunction in Osteoarthritis Rat. Inflammation. 2017, 40(6): 2086–2093

8/2017     Antiproliferative Activity of Crocin Involves Targeting of Microtubules in Breast Cancer Cells. Scientific Reports 7, Article number: 44984 (2017) doi:10.1038/srep44984

7/2017   Effects of Saffron Aqueous Extract and Its Main Constituent, Crocin, on Health-Related Quality of Life, Depression, and Sexual Desire in Coronary Artery Disease Patients: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial. Iranian Red Crescent Medical Journal. 2017, 19 (9); e13676

7/2017    Inhibition of Inflammatory Response by Crocin Attenuates Hemorrhagic Shock-Induced Organ Damages in Rats. Journal of Interferon & Cytokine Research. 2017, 37(7): 295-302.

6/2017     Crocin attenuates hemorrhagic shock-induced oxidative stress and organ injuries in rats. Environmental Toxicology and Pharmacology. 2017, 52: 177-182

5/2017     Pre-supplementation of Crocus sativus Linn (saffron) attenuates inflammatory and lipid peroxidation markers induced by intensive exercise in sedentary women. Journal of Applied Pharmaceutical Science 2017, 7(5): 147-151.

5/2017     Crocus sativus extract tighten the blood-brain barrier, reduces amyloid-β load and related toxicity in 5XFAD mice. ACS Chem. Neurosci., 2017, 8(8): 1756–1766

5/2017     Crocin Attenuates Kindling Development and Associated Cognitive Impairments in Mice via Inhibiting Reactive Oxygen Species-Mediated NF-κB Activation. Basic & Clinical Pharmacology & Toxicology. 2017, 120(5):  426–433

3/2017     Crocin improves spatial learning and memory deficits in the Morris water maze via attenuating cortical oxidative damage in diabetic rats. Neuroscience Letters. 2017, 642: 1-6.

3/2017    Crocins, the active constituents of Crocus sativus L., counteracted apomorphine-induced performance deficits in the novel object recognition task, but not novel object location task, in rats. Neuroscience Letters. 2017, 644: 37-42

3/2017   Antiproliferative Activity of Crocin Involves Targeting of Microtubules in Breast Cancer Cells. Scientific Reports. 2017, 7:44984. DOI: 10.1038/srep44984

3/2017     Role of Dietary Crocin in In Vivo Melanoma Tumor Remission. Asian Pac J Cancer Prev, 2017, 18(3): 841-846

3/2017     Protective effect of Crocus sativus L. (Saffron) extract on spinal cord ischemia-reperfusion injury in rats. Iran J Basic Med Sci. 2017, 20(3): 334–337.

2/2017     Saffron in the treatment of depression, anxiety and other mental disorders: Current evidence and potential mechanisms of action. Journal of Affective Disorders. 2017, 227: 330-337.

1/2017     Crocin protects against cerebral- ischemia-induced damage in aged rats through maintaining the integrity of blood-brain barrier. Restorative Neurology and Neuroscience, 2017, 35(1): 65-75.

1/2017    Trans-crocetin improves amyloid-β degradation in monocytes from Alzheimer's Disease patients. Journal of the Neurological Sciences. 2017, 372: 408-412