From Challenge to Clarity: Our Journey to Transparency and Scientific Integrity

At Saffron Health Sciences, we are a small business with a bold mission: to develop science-based ingredients and create supplements for daily vitality and healthy aging that are genuinely effective, rooted in real clinical research.

Our flagship innovation, Crocin Rich®, is the only high-purity natural crocin ingredient on the market and is recognized by the FDA as a New Dietary Ingredient (NDI). This milestone underscores our commitment to scientific rigor, ingredient integrity, and regulatory compliance.

Like many companies that push boundaries, we faced a challenge in 2021. The U.S. FDA issued a Warning Letter CMS #615429 not because of our formulations, labels, or product safety—which were fully compliant—but due to certain educational blog content and website descriptions that cited published studies referencing disease names. While the intent was to inform the public about scientific findings, combining these citations with the sale of dietary supplements is interpreted by the FDA as an impermissible health claim under U.S. regulations.

We acted swiftly and responsibly. Within days, we communicated with the corresponding officer at the FDA, removed all disease-name references from our blogs, and replaced study descriptions with compliant links to the original sources. We ensured that no disease prevention or treatment language appeared anywhere on our commercial sites. In recognition of our corrective actions, the FDA officially issued the Closeout Letter to the Warning Letter CMS #615429 in two months, on January 18, 2022.

This experience reinforced what we already believed: that scientific communication must balance clarity with compliance. We remain committed to transparency, innovation, and the highest ethical standards.

Backed by dozens of published crocin clinical studies, our high-purity Crocin Rich® ingredient serves as the foundation for our supplement line, including CROCIN RICH, CROCIN RICH II, and CROCIN RICH Plus. We are proud to offer consumers crocin doses that are clinically effective, accurately labeled, and manufactured to the highest quality standards in an NSF-certified facility in New Jersey.

As a founder-led business, every decision we make is driven by science and users’ benefits in our hearts, not trends. And every supplement we produce is built on a foundation of integrity and evidence.

We thank our customers, partners, and the scientific community for their continued support. Our mission continues: to bring meaningful, effective health solutions to market, one crocin tablet at a time.