Saffron Supplementation in Early Age-Related Macular Degeneration

Reading time: 20+ minutes
Level of expertise: High

In 2012, 10 researchers M. Piccardi, D.Marangoni, A. M.Minnella, M. C. Savastano, P. Valentini, L. Ambrosio, E. Capoluongo, R.Maccarone, S. Bisti, and B. Falsini from Italy and Australia published a paper about the effects saffron supplements have on macular degeneration diseases. They conducted a clinical trial study with almost 30 patients to see how saffron affected their eye health. 

Followings are from the original paper:

Objectives: In a previous randomized clinical trial (Falsini et al. (2010)), it was shown that short-term Saffron supplementation improves retinal flicker sensitivity in early age-relatedmacular degeneration (AMD). The aim of this study was to evaluate whether the observed functional benefits fromSaffron supplementation may extend over a longer follow-up duration.

Design: Longitudinal, interventional open-label study.

Setting: Outpatient ophthalmology setting.

Participants: Twenty-nine early AMD patients (age range: 55–85 years) with a baseline visual acuity >0.3. Intervention. Saffron oral supplementation (20mg/day) over an average period of treatment of 14 (°æ2) months.Measurements. Clinical examination and focal-electroretinogram-(fERG-) derived macular (18) flicker sensitivity estimate (Falsini et al. (2010)) every three months over a followup of 14 (°æ2) months. Retinal sensitivity, the reciprocal value of the estimated fERG amplitude threshold, was the main outcome measure.

Results: After three months of supplementation, mean fERG sensitivity improved by 0.3 log units compared to baseline values (P < 0.01), and mean visual acuity improved by two Snellen lines compared to baseline values (0.75 to 0.9, P < 0.01). These changes remained stable over the followup period. Conclusion. These results indicate that in early AMD Saffron supplementation induces macular function improvements from baseline that are extended over a long-term followup.

For more information regarding this paper, please click here.

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2012, Article ID 429124, 9 pages doi:10.1155/2012/429124


Leave a comment

Please note, comments must be approved before they are published